Basic information
PhaSepDB ID psself78 Reference 29425497 Uniprot Entry P35637 Gene names FUS
Class PS-self Location Cytoplasm MLO Stress granule
LLPS related evidences
Publication note We observed that LLPS of SNAP fusions of FUSIDR is strongly impaired in yeast lysates, which contained ∼10 mg/mL protein. We observed LLPS with identical concentrations of RNA and SNAP-PTB, when SNAP-PTB was fused to either the FUS or Pub1 IDRs. Phase-separated droplets formed at 37.5 mM NaCl by SNAP-hnRNP A1IDR, SNAP-FUSIDR, SNAP-eIF4GIIIDR in the absence or presence of 100 mg/mL BSA, lysozyme, or RNase A.
(Organism: Homo sapiens; Cell line: _)
Material state liquid : Phase-separated droplets formed by SNAP-eIF4GIIIDR (35 µM), SNAP-hnRNP A1IDR (5.25 µM), or SNAP-FUSIDR (5 µM) in the presence of either 10 nM FITC-BSA or 100 nM FITC-lysozyme.
LLPS region 1-237 Key domains _ : _
LLPS partner
Protein partner

PTB ( Q9UKA9 )

 we observed LLPS with identical concentrations of RNA and SNAP-PTB, when SNAP-PTB was fused to either the FUS or Pub1 IDRs
RNA partner

(UCUCUAAAAA)5

 we observed LLPS with identical concentrations of RNA and SNAP-PTB, when SNAP-PTB was fused to either the FUS or Pub1 IDRs
Others

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LLPS regulation
PTM

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Mutation

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Alternative splicing _
Repeat _
Oligomerization _