Basic information
PhaSepDB ID psself205 Reference 32386547 Uniprot Entry P20226 Gene names TBP
Class PS-self Location Nucleus MLO Transcriptional condensate
LLPS related evidences
Publication note Disease-associated repeat expansions in other TFs (HOXA13, RUNX2, and TBP) were similarly found to alter their phase separation. The TBP IDR can drive phase separation, and its phase separation capacity is inhibited by pathological glutamine repeat expansion.
(Organism: Homo sapiens; Cell line: HEK293T Cells)
Material state liquid : TBP IDR droplets exhibited liquid-like FRAP rate.
LLPS region 1-160 Key domains intrinsically disordered region (IDR) : The TBP IDR can drive phase separation, and its phase separation capacity is inhibited by pathological glutamine repeat expansion.
LLPS partner
Protein partner

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RNA partner

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Others

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LLPS regulation
PTM

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Mutation

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Alternative splicing _
Repeat The TBP IDR can drive phase separation, and its phase separation capacity is inhibited by pathological glutamine repeat expansion.
Oligomerization _