| Description |
In mammalian neurons, mRNAs to be targeted to these distant sites can be packaged into Neuronal granules (NGs), where they can remain translationally repressed until they are released at their final destination and translated in response to specific exogenous stimuli. Like stress granules (SGs), NGs contain mRNA, small and large ribosomal subunits, translation initiation factors and RNA-binding proteins that regulate mRNA function. Despite possessing ribosomes, mRNAs present within NGs are probably not translated until they reach the synapse, where their translation may require activating stimuli. SGs and NGs possess many of the same protein components, and Staufen, for example, can be transferred from NGs to SGs during stress in rat oligodendrocytes. |