| MLO Description | |||||
|---|---|---|---|---|---|
| MLO | Mediator condensate | Synonym | _ | Location | Nucleus |
| Description | Master transcription factors (TFs) and the Mediator coactivator form phase-separated condensates at super-enhancers, which compartmentalize and concentrate the transcription apparatus at key cell identity genes. Hundreds of molecules of Pol II and mediator are concentrated in condensates at super-enhancers and large numbers of splicing factors are concentrated in nuclear speckles, some of which occur at highly active transcription sites. | ||||
| Reference | 31391587,31563432 | ||||