| Description |
The transcription factors (TFs) regulating cell identity contain prion-like domains (PrLDs) that enable liquid-liquid demixing and the formation of phase-separated condensates. The assembly of the transcription machinery at genomic sites occurs through liquid-liquid phase separation, leading to the formation of transcriptional condensates. Repeat expansions in intrinsically disordered regions (IDRs) of transcription factors (TFs) alter the phase separation capacity of those TFs, and their capacity to form transcriptional condensates with components of the transcription machinery. |