| MLO Description | |||||
|---|---|---|---|---|---|
| MLO | Histone locus body | Synonym | _ | Location | Nucleus |
| Description | The histone locus body (HLB) contains factors required for processing histone pre-mRNAs[1]. Production of histone mRNAs occurs in HLB, a subdomain of the nucleus defined by a concentration of factors necessary for histone gene transcription and pre-mRNA processing. HLB formation involves a combination of ordered and stochastic assembly steps, and cell cycle regulated changes in the HLB occur to activate histone gene expression during S phase[2]. | ||||
| Reference | 20504965,28059623 | ||||